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Article

An RNA-dependent RNA polymerase gene in bat genomes derived from an ancient negative-strand RNA virus

13 May 2016

Abstract excerpt

Endogenous bornavirus-like L (EBLL) elements are inheritable sequences derived from ancient bornavirus L genes that encode a viral RNA-dependent RNA polymerase (RdRp) in many eukaryotic genomes. Here, we demonstrate that bats of the genus Eptesicus have preserved for more than 11.8 million years an EBLL element named eEBLL-1, which has an intact open reading frame of 1,718 codons. The eEBLL-1 coding sequence...

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PMID: 27174689
DOI: 10.1038/srep25873

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