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Article

Blood biomarkers in a mouse model of CADASIL.

Brain research - 1 Aug 2016

Primo Vincent, Graham Mark, Bigger-Allen Alexander A, Chick Joel M, Ospina Carolina, Quiroz Yakeel T, Manent Jan, Gygi Steven P, Lopera Francisco, D'Amore Patricia A, Arboleda-Velasquez Joseph F

Abstract excerpt

Mutations in NOTCH 3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a neurological disorder characterized by stroke, and vascular cognitive impairment and dementia. Loss of vascular smooth muscle cells (VSMC) and accumulation of granular osmiophilic material (GOM) deposits are hallmarks of CADASIL. There are no therapies for CADASIL and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27174004
DOI: 10.1016/j.brainres.2016.05.008

Genes

HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Blood biomarkers in a mouse model of CADASIL.PMID 27174004Read ↗

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Age-dependent vascular and neurological characteristics of CADASIL are recapitulated in Notch3 mutant zebrafish, implicating a role for type IV collagen in disease progression.Semantic proximity Read ↗

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