Article
Bacteria in an intense competition for iron: Key component of the Campylobacter jejuni iron uptake system scavenges enterobactin hydrolysis product.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 2016
Raines Daniel J, Moroz Olga V, Blagova Elena V, Turkenburg Johan P, Wilson Keith S, Duhme-Klair Anne-K
Abstract excerpt
To acquire essential Fe(III), bacteria produce and secrete siderophores with high affinity and selectivity for Fe(III) to mediate its uptake into the cell. Here, we show that the periplasmic binding protein CeuE of Campylobacter jejuni, which was previously thought to bind the Fe(III) complex of the hexadentate siderophore enterobactin (Kd ∼ 0.4 ± 0.1 µM), preferentially binds the Fe(III) complex of the...
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