Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.

doi:10.1186/s12967-016-0882-0

Article

Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.

Journal of translational medicine - 10 May 2016

Larsson Anna H, Lehn Sophie, Wangefjord Sakarias, Karnevi Emelie, Kuteeva Eugenia, Sundström Magnus, Nodin Björn, Uhlén Mathias, Eberhard Jakob, Birgisson Helgi, Jirström Karin

Abstract excerpt

BACKGROUND: Podocalyxin-like 1 (PODXL) is an anti-adhesive transmembrane protein that has been demonstrated to be an independent factor of poor prognosis in colorectal cancer (CRC). The gene encoding PODXL is located to chromosome 7, which also harbours the gene for the epidermal growth factor receptor (EGFR). The aim of this study was to examine the associations between PODXL and EGFR expression in CRC in vitro...

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Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.

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