Article
A Mutation in LTBP2 Causes Congenital Glaucoma in Domestic Cats (Felis catus).
PloS one - 1 Jan 2016
Kuehn Markus H, Lipsett Koren A, Menotti-Raymond Marilyn, Whitmore S Scott, Scheetz Todd E, David Victor A, O'Brien Stephen J, Zhao Zhongyuan, Jens Jackie K, Snella Elizabeth M, Ellinwood N Matthew, McLellan Gillian J
Abstract excerpt
The glaucomas are a group of diseases characterized by optic nerve damage that together represent a leading cause of blindness in the human population and in domestic animals. Here we report a mutation in LTBP2 that causes primary congenital glaucoma (PCG) in domestic cats. We identified a spontaneous form of PCG in cats and established a breeding colony segregating for PCG consistent with fully penetrant,...
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