Article
Alternative Splicing of IGF1 Gene as a Potential Factor in the Pathogenesis of Peyronie's Disease.
In vivo (Athens, Greece) - 1 Jan 2000
Thomas Charalampos G, Psarros Constantinos, Gekas Aristomenis, Vandoros Gerasimos P, Philippou Anastasios, Koutsilieris Michael
Abstract excerpt
BACKGROUND/AIM: Peyronie's disease (PD) is a fibrotic entity for which the pathogenetic mechanism remains unclear and if resulting in severe deformity, its treatment is only surgical. In this study we investigated the possible role of insulin-like growth factor 1 (IGF1) expression in the pathogenesis of PD. MATERIALS AND METHODS: Tissue samples were obtained from plaques of 24 patients with PD. The expression of...
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