AN ANIMAL MODEL OF PEYRONIE'S-LIKE CONDITION ASSOCIATED WITH AN INCREASE OF TRANSFORMING GROWTH FACTOR BETA mRNA AND PROTEIN EXPRESSION

Abstract excerpt

PURPOSE: Transforming growth factor beta (TGF-beta) is involved in numerous vital processes including tissue fibrosis. Our objective was to study the role of TGF-beta in the induction of a Peyronie's-like condition and to produce an animal model for the further study of Peyronie's disease. MATERIALS AND METHODS: Twenty-four adult male Sprague-Dawley rats were divided into two groups. Different concentrations of...

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