Article
Effects of amino acid mutations in the pore-forming domain of the hemolytic lectin CEL-III.
Bioscience, biotechnology, and biochemistry - 1 Oct 2016
Nagao Tomonao, Masaki Risa, Unno Hideaki, Goda Shuichiro, Hatakeyama Tomomitsu
Abstract excerpt
The hemolytic lectin CEL-III forms transmembrane pores in the membranes of target cells. A study on the effect of site-directed mutation at Lys405 in domain 3 of CEL-III indicated that replacements of this residue by relatively smaller residues lead to a marked increase in hemolytic activity, suggesting that moderately destabilizing domain 3 facilitates formation of transmembrane pores through conformational changes.
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