Diffusion Retardation by Binding of Tobramycin in an Alginate Biofilm Model

Abstract excerpt

Microbial cells embedded in a self-produced extracellular biofilm matrix cause chronic infections, e. g. by Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. The antibiotic killing of bacteria in biofilms is generally known to be reduced by 100-1000 times relative to planktonic bacteria. This makes such infections difficult to treat. We have therefore proposed that biofilms can be regarded as an...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antimicrobial Resistance in Staphylococcus
• Share to Bacterial biofilms and quorum sensing
• Share to Mycobacterium research and diagnosis