The Drosophila melanogaster model for Cornelia de Lange syndrome: Implications for etiology and therapeutics.

Abstract excerpt

Discovery of genetic alterations that cause human birth defects provide key opportunities to improve the diagnosis, treatment, and family counseling. Frequently, however, these opportunities are limited by the lack of knowledge about the normal functions of the affected genes. In many cases, there is more information about the gene's orthologs in model organisms, including Drosophila melanogaster. Despite almost...

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