Article
High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing.
GigaScience - 1 Jan 2016
Peng Chao, Yao Ge, Gao Bing-Miao, Fan Chong-Xu, Bian Chao, Wang Jintu, Cao Ying, Wen Bo, Zhu Yabing, Ruan Zhiqiang, Zhao Xiaofei, You Xinxin, Bai Jie, Li Jia, Lin Zhilong, Zou Shijie, Zhang Xinhui, Qiu Ying, Chen Jieming, Coon Steven L, Yang Jiaan, Chen Ji-Sheng, Shi Qiong
Abstract excerpt
BACKGROUND: The venom of predatory marine cone snails mainly contains a diverse array of unique bioactive peptides commonly referred to as conopeptides or conotoxins. These peptides have proven to be valuable pharmacological probes and potential drugs because of their high specificity and affinity to important ion channels, receptors and transporters of the nervous system. Most previous studies have focused...
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