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Combined proteomic and transcriptomic interrogation of the venom gland of Conus geographus uncovers novel components and functional compartmentalization.

Molecular & cellular proteomics : MCP - 1 Apr 2014

Safavi-Hemami Helena, Hu Hao, Gorasia Dhana G, Bandyopadhyay Pradip K, Veith Paul D, Young Neil D, Reynolds Eric C, Yandell Mark, Olivera Baldomero M, Purcell Anthony W

Abstract excerpt

Cone snails are highly successful marine predators that use complex venoms to capture prey. At any given time, hundreds of toxins (conotoxins) are synthesized in the secretory epithelial cells of the venom gland, a long and convoluted organ that can measure 4 times the length of the snail's body. In recent years a number of studies have begun to unveil the transcriptomic, proteomic and peptidomic complexity of...

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Identifiers

PMID: 24478445
DOI: 10.1074/mcp.M113.031351
PMCID: PMC3977193

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