Article
Incidentalome from Genomic Sequencing: A Barrier to Personalized Medicine?
EBioMedicine - 1 Mar 2016
Jamuar Saumya Shekhar, Kuan Jyn Ling, Brett Maggie, Tiang Zenia, Tan Wilson Lek Wen, Lim Jiin Ying, Liew Wendy Kein Meng, Javed Asif, Liew Woei Kang, Law Hai Yang, Tan Ee Shien, Lai Angeline, Ng Ivy, Teo Yik Ying, Venkatesh Byrappa, Reversade Bruno, Tan Ene Choo, Foo Roger
Abstract excerpt
BACKGROUND: In Western cohorts, the prevalence of incidental findings (IFs) or incidentalome, referring to variants in genes that are unrelated to the patient's primary condition, is between 0.86% and 8.8%. However, data on prevalence and type of IFs in Asian population is lacking. METHODS: In 2 cohorts of individuals with genomic sequencing performed in Singapore (total n = 377), we extracted and annotated...
Topics
- Chromosome Mapping
- Databases, Genetic
- Exome
- Genetic Variation
- Genome, Human
- Genomics
- High-Throughput Nucleotide Sequencing
- Humans
- Incidental Findings
- Molecular Sequence Annotation