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Article

Aberrant expression of microRNA-99a and its target gene mTOR associated with malignant progression and poor prognosis in patients with osteosarcoma

1 Mar 2016

Abstract excerpt

BACKGROUND: The mammalian target of rapamycin (mTOR) has been reported to act as a target gene of microRNA (miR)-99a in various cancer cells and identified as an independent prognostic marker of human osteosarcoma. The aim of this study was to investigate the clinical significance of miR-99a/mTOR axis in human osteosarcoma. METHODS: A total of 130 pairs of osteosarcoma and matched noncancerous bone tissues were...

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PMID: 27073323
DOI: 10.2147/ott.s102421

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