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The assessment of HER2 status in breast cancer: the past, the present, and the future

7 Apr 2016

Abstract excerpt

Humanized monoclonal anti-human growth factor receptor 2 (HER2) antibody trastuzumab was approved for HER2 positive breast cancer patient treatment 11 years after the demonstration of HER2 gene amplification associated with the HER2 protein overexpression in breast cancer in 1987. HER2 positive status of breast cancer patients is assessed by HER2 gene amplification with in situ hybridization (ISH) and/or HER2...

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PMID: 27061008
DOI: 10.1111/pin.12407

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