Article
Effectiveness of Pentavalent Rotavirus Vaccine Against a Diverse Range of Circulating Strains in Nicaragua.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 May 2016
Patel Manish, Pedreira Cristina, De Oliveira Lúcia Helena, Tate Jacqueline, Leshem Eyal, Mercado Juan, Umaña Jazmina, Balmaceda Angel, Reyes Martha, Kerin Tara, McDonald Sharla, Gentsch Jon, Bowen Michael D, Parashar Umesh
Abstract excerpt
BACKGROUND: Because >60 rotavirus strains have been reported worldwide, concerns exist about strain replacement after the introduction of rotavirus vaccines, particularly in developing countries with diverse strains and lower efficacy. METHODS: We used the case-control design in 4 hospitals in Nicaragua to assess strain-specific vaccine effectiveness (VE) of a pentavalent rotavirus vaccine (RotaTeq) against...
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