Prospective Evaluation of First-Line Erlotinib in Advanced Non-Small Cell Lung Cancer (NSCLC) Carrying an Activating EGFR Mutation: A Multicenter Academic Phase II Study in Caucasian Patients (FIELT).

doi:10.1371/journal.pone.0147599

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Prospective Evaluation of First-Line Erlotinib in Advanced Non-Small Cell Lung Cancer (NSCLC) Carrying an Activating EGFR Mutation: A Multicenter Academic Phase II Study in Caucasian Patients (FIELT).

PloS one - 1 Jan 2016

De Grève Jacques, Van Meerbeeck Jan, Vansteenkiste Johan F, Decoster Lore, Meert Anne-Pascale, Vuylsteke Peter, Focan Christian, Canon Jean-Luc, Humblet Yves, Berchem Guy, Colinet Benoit, Galdermans Danny, Bosquée Lionel, Vermeij Joanna, Dewaele Alex, Geers Caroline, Schallier Denis, Teugels Erik

Abstract excerpt

INTRODUCTION: Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibition is the preferred first-line treatment of advanced adenocarcinoma of the lung that harbors EGFR activating tyrosine kinase domain mutations. Most data available pertain to Asian populations in which such mutations are more prevalent. We report on the long-term results of first-line treatment with erlotinib in Caucasian patients with...

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PMID: 27032107
DOI: 10.1371/journal.pone.0147599
PMCID: PMC4816447

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