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Article

Complex regional pain syndrome: evidence for warm and cold subtypes in a large prospective clinical sample.

Pain - 1 Aug 2016

Bruehl Stephen, Maihöfner Christian, Stanton-Hicks Michael, Perez Roberto S G M, Vatine Jean-Jacques, Brunner Florian, Birklein Frank, Schlereth Tanja, Mackey Sean, Mailis-Gagnon Angela, Livshitz Anatoly, Harden R Norman

Abstract excerpt

Limited research suggests that there may be Warm complex regional pain syndrome (CRPS) and Cold CRPS subtypes, with inflammatory mechanisms contributing most strongly to the former. This study for the first time used an unbiased statistical pattern recognition technique to evaluate whether distinct Warm vs Cold CRPS subtypes can be discerned in the clinical population. An international, multisite study was...

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PMID: 27023422
DOI: 10.1097/j.pain.0000000000000569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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