Article
Fine-tuning of Substrate Affinity Leads to Alternative Roles of Mycobacterium tuberculosis Fe2+-ATPases.
The Journal of biological chemistry - 27 May 2016
Patel Sarju J, Lewis Brianne E, Long Jarukit E, Nambi Subhalaxmi, Sassetti Christopher M, Stemmler Timothy L, Argüello José M
Abstract excerpt
Little is known about iron efflux transporters within bacterial systems. Recently, the participation of Bacillus subtilis PfeT, a P1B4-ATPase, in cytoplasmic Fe(2+) efflux has been proposed. We report here the distinct roles of mycobacterial P1B4-ATPases in the homeostasis of Co(2+) and Fe(2+) Mutation of Mycobacterium smegmatis ctpJ affects the homeostasis of both ions. Alternatively, an M. tuberculosis ctpJ...
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