Brucella ovis PA mutants for outer membrane proteins Omp10, Omp19, SP41, and BepC are not altered in their virulence and outer membrane properties.

doi:10.1016/j.vetmic.2016.02.010

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Article

Brucella ovis PA mutants for outer membrane proteins Omp10, Omp19, SP41, and BepC are not altered in their virulence and outer membrane properties.

Veterinary microbiology - 15 Apr 2016

Sidhu-Muñoz Rebeca S, Sancho Pilar, Vizcaíno Nieves

Abstract excerpt

Mutants in several genes have been obtained on the genetic background of virulent rough (lacking O-polysaccharide) Brucella ovis PA. The target genes encode outer membrane proteins previously associated with the virulence of smooth (bearing O-polysaccharide chains in the lipopolysaccharide) Brucella strains. Multiple attempts to delete omp16, coding for a homologue to peptidoglycan-associated lipoproteins, were...

Topics

Animals
Bacterial Outer Membrane Proteins
Brucella
Brucella ovis
Brucellosis
Cell Line
Cell Membrane
Female
Gene Silencing
HeLa Cells
Humans
Macrophages
Mice
Mice, Inbred BALB C
Mutation
Random Allocation
Spleen
Stem Cells

Source

Open in PubMed

Identifiers

PMID: 27016758
DOI: 10.1016/j.vetmic.2016.02.010

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