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Article

Coding exon-structure aware realigner (CESAR) utilizes genome alignments for accurate comparative gene annotation.

Nucleic acids research - 20 Jun 2016

Sharma Virag, Elghafari Anas, Hiller Michael

Abstract excerpt

Identifying coding genes is an essential step in genome annotation. Here, we utilize existing whole genome alignments to detect conserved coding exons and then map gene annotations from one genome to many aligned genomes. We show that genome alignments contain thousands of spurious frameshifts and splice site mutations in exons that are truly conserved. To overcome these limitations, we have developed CESAR...

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Identifiers

PMID: 27016733
DOI: 10.1093/nar/gkw210
PMCID: PMC4914097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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