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Polymorphisms in human telomerase reverse transcriptase (hTERT) gene and susceptibility to gastric cancer in a Turkish population: Hospital-based case-control study.

Gene - 1 Jul 2016

Bayram Süleyman, Ülger Yakup, Sümbül Ahmet Taner, Kaya Berrin Yalinbaş, Genç Ahmet, Rencüzoğullari Eyyüp, Dadaş Erdoğan

Abstract excerpt

Erosion of telomeres, tandem nucleotide repeats (TTAGGG)n that cap the end of eukaryotic chromosomes, has been related with carcinogenesis. The human telomerase reverse transcriptase (hTERT) gene is encoded the rate-limiting catalytic subunit of the telomerase complexes, which is essential for the protection of telomeric DNA length and chromosomal stability. The purpose of this study was to examine the effect of...

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PMID: 27016301
DOI: 10.1016/j.gene.2016.03.030

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