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Article

Cell-type-specific miR-431 dysregulation in a motor neuron model of spinal muscular atrophy

22 Mar 2016

Abstract excerpt

Spinal muscular atrophy (SMA) is an autosomal-recessive pediatric neurodegenerative disease characterized by selective loss of spinal motor neurons. It is caused by mutation in the survival of motor neuron 1, SMN1, gene and leads to loss of function of the full-length SMN protein. microRNAs (miRNAs) are small RNAs that are involved in post-transcriptional regulation of gene expression. Prior studies have...

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PMID: 27005422
DOI: 10.1093/hmg/ddw084

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