Article
Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria.
Nature communications - 22 Mar 2016
Sundararaman Sesh A, Plenderleith Lindsey J, Liu Weimin, Loy Dorothy E, Learn Gerald H, Li Yingying, Shaw Katharina S, Ayouba Ahidjo, Peeters Martine, Speede Sheri, Shaw George M, Bushman Frederic D, Brisson Dustin, Rayner Julian C, Sharp Paul M, Hahn Beatrice H
Abstract excerpt
African apes harbour at least six Plasmodium species of the subgenus Laverania, one of which gave rise to human Plasmodium falciparum. Here we use a selective amplification strategy to sequence the genome of chimpanzee parasites classified as Plasmodium reichenowi and Plasmodium gaboni based on the subgenomic fragments. Genome-wide analyses show that these parasites indeed represent distinct species, with no...
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