Article
The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype.
BMC biology - 17 Mar 2016
Bagchi Rushita A, Roche Patricia, Aroutiounova Nina, Espira Leon, Abrenica Bernard, Schweitzer Ronen, Czubryt Michael P
Abstract excerpt
BACKGROUND: Resident fibroblasts synthesize the cardiac extracellular matrix, and can undergo phenotype conversion to myofibroblasts to augment matrix production, impairing function and contributing to organ failure. A significant gap in our understanding of the transcriptional regulation of these processes exists. Given the key role of this phenotype conversion in fibrotic disease, the identification of such...
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