Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic identification of phenotypically enriched loci using a patient network of genomic disorders.

BMC genomics - 15 Mar 2016

Reyes-Palomares Armando, Bueno Aníbal, Rodríguez-López Rocío, Medina Miguel Ángel, Sánchez-Jiménez Francisca, Corpas Manuel, Ranea Juan A G

Abstract excerpt

BACKGROUND: Network medicine is a promising new discipline that combines systems biology approaches and network science to understand the complexity of pathological phenotypes. Given the growing availability of personalized genomic and phenotypic profiles, network models offer a robust integrative framework for the analysis of "omics" data, allowing the characterization of the molecular aetiology of pathological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Databases, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Genetic Association Studies

Share to Genetic Diseases, Inborn

Share to Genetic Loci

Share to Genomics

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 26980139
DOI: 10.1186/s12864-016-2569-6
PMCID: PMC4792099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic identification of phenotypically enriched loci using a patient network of genomic disorders.PMID 26980139Read ↗

Phenotype-loci associations in networks of patients with rare disorders: application to assist in the diagnosis of novel clinical cases.Semantic proximity Read ↗

Gene networks underlying convergent and pleiotropic phenotypes in a large and systematically-phenotyped cohort with heterogeneous developmental disorders.Semantic proximity Read ↗

Systematic identification of genetic systems associated with phenotypes in patients with rare genomic copy number variations.Semantic proximity Read ↗

Unbiased functional clustering of gene variants with a phenotypic-linkage network.Semantic proximity Read ↗

Symptom-driven idiopathic disease gene identification.Semantic proximity Read ↗

Network properties of genes harboring inherited disease mutations.Semantic proximity Read ↗

Network analysis reveals rare disease signatures across multiple levels of biological organization.Semantic proximity Read ↗

Leveraging network analytics to infer patient syndrome and identify causal genes in rare disease cases.Semantic proximity Read ↗

PANGEN: an online platform for the comparison and creation of diagnostic gene panels.Semantic proximity Read ↗

A global survey of systems biology-based predictions of gene-rare disease associations to enhance new diagnoses.Semantic proximity Read ↗

Rapid and Accurate Interpretation of Clinical Exomes Using Phenoxome: a Computational Phenotype-driven ApproachSemantic proximity Read ↗

A global survey of System Biology-based predictions of gene-rare disease associations to enhance new diagnosesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.