Article
Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down.
Cancer cell - 14 Mar 2016
Hobbs G Aaron, Wittinghofer Alfred, Der Channing J
Abstract excerpt
Two recent studies evaluated a small molecule that specifically binds to and inactivates the KRAS G12C mutant. The new findings argue that the perception that mutant KRAS is persistently frozen in its active GTP-bound form may not be accurate.
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