Article
Molecular Characterization of β-Thalassemia in the Czech and Slovak Populations: Mediterranean, Asian and Unique Mutations.
Hemoglobin - 1 Jun 2016
Divoka Martina, Partschova Martina, Kucerova Jana, Mojzikova Renata, Cermak Jaroslav, Pospisilova Dagmar, Fabryova Viera, Prochazkova Daniela, Indrak Karel, Divoky Vladimir
Abstract excerpt
β-Thalassemia (β-thal) is considered rare in Central Europe. As in other malaria-free regions, the presence of β-thal in Central Europe reflects historical and recent immigration, and demographic changes that have influenced the genetic variability of the current populations living in this area. This study assesses the frequency and spectrum of mutations on the β-globin gene in Czech and Slovak subjects with...
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