X-Linked Agammagobulinemia in a Large Series of North African Patients: Frequency, Clinical Features and Novel BTK Mutations.

doi:10.1007/s10875-016-0251-z

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Article

X-Linked Agammagobulinemia in a Large Series of North African Patients: Frequency, Clinical Features and Novel BTK Mutations.

Journal of clinical immunology - 1 Apr 2016

Aadam Zahra, Kechout Nadia, Barakat Abdelhamid, Chan Koon-Wing, Ben-Ali Meriem, Ben-Mustapha Imen, Zidi Fethi, Ailal Fatima, Attal Nabila, Doudou Fatouma, Abbadi Mohamed-Cherif, Kaddache Chawki, Smati Leila, Touri Nabila, Chemli Jalel, Gargah Tahar, Brini Ines, Bakhchane Amina, Charoute Hicham, Jeddane Leila, El Atiqi Sara, El Hafidi Naïma, Hida Mustapha, Saile Rachid, Alj Hanane Salih, Boukari Rachida, Bejaoui Mohamed, Najib Jilali, Barbouche Mohamed-Ridha, Lau Yu-Lung, Mellouli Fethi, Bousfiha Ahmed Aziz

Abstract excerpt

PURPOSE: X-linked agammagobulinemia (XLA) is a primary immunodeficiency caused by Bruton's tyrosine kinase (BTK) gene defect. XLA patients have absent or reduced number of peripheral B cells and a profound deficiency in all immunoglobulin isotypes. This multicenter study reports the clinical, immunological and molecular features of Bruton's disease in 40 North African male patients. METHODS: Fifty male out of 63...

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PMID: 26931785
DOI: 10.1007/s10875-016-0251-z

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