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Article

Caspase-1 Plays a Critical Role in Accelerating Chronic Kidney Disease-Promoted Neointimal Hyperplasia in the Carotid Artery.

Journal of cardiovascular translational research - 1 Apr 2016

Ferrer Lucas M, Monroy Alexandra M, Lopez-Pastrana Jahaira, Nanayakkara Gayani, Cueto Ramon, Li Ya-Feng, Li Xinyuan, Wang Hong, Yang Xiao-Feng, Choi Eric T

Abstract excerpt

To determine whether caspase-1 is critical in chronic kidney disease (CKD)-mediated arterial neointimal hyperplasia (NH), we utilized caspase(-/-) mice and induced NH in carotid artery in a CKD environment, and uremic sera-stimulated human vascular smooth muscle cells (VSMC). We made the following findings: (1) Caspase-1 inhibition corrected uremic sera-mediated downregulation of VSMC contractile markers, (2)...

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Identifiers

PMID: 26928596
DOI: 10.1007/s12265-016-9683-3
PMCID: PMC5131710

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