Article
Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension.
American journal of respiratory and critical care medicine - 15 Aug 2016
Hemnes Anna R, Zhao Min, West James, Newman John H, Rich Stuart, Archer Stephen L, Robbins Ivan M, Blackwell Timothy S, Cogan Joy, Loyd James E, Zhao Zhongming, Gaskill Christa, Jetter Christopher, Kropski Jonathan A, Majka Susan M, Austin Eric D
Abstract excerpt
RATIONALE: Idiopathic pulmonary arterial hypertension (IPAH) is usually without an identified genetic cause, despite clinical and molecular similarity to bone morphogenetic protein receptor type 2 mutation-associated heritable pulmonary arterial hypertension (PAH). There is phenotypic heterogeneity in IPAH, with a minority of patients showing long-term improvement with calcium channel-blocker therapy. OBJECTIVES:...
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