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A <i>Plasmodium falciparum</i> PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface

30 Jun 2014

Abstract excerpt

Uniquely among malaria parasites, Plasmodium falciparum‐infected erythrocytes (iRBCs) develop membrane protrusions, known as knobs, where the parasite adhesion receptor P. falciparum erythrocyte membrane protein 1 (PfEMP1) clusters. Knob formation and the associated iRBC adherence to host endothelium are directly linked to the severity of malaria and are functional manifestations of protein export from the...

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PMID: 24983468
DOI: 10.1096/fj.14-256057

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