Article
Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck.
Genome research - 1 Apr 2016
Li Mingkun, Rothwell Rebecca, Vermaat Martijn, Wachsmuth Manja, Schröder Roland, Laros Jeroen F J, van Oven Mannis, de Bakker Paul I W, Bovenberg Jasper A, van Duijn Cornelia M, van Ommen Gert-Jan B, Slagboom P Eline, Swertz Morris A, Wijmenga Cisca, Kayser Manfred, Boomsma Dorret I, Zöllner Sebastian, de Knijff Peter, Stoneking Mark
Abstract excerpt
Although previous studies have documented a bottleneck in the transmission of mtDNA genomes from mothers to offspring, several aspects remain unclear, including the size and nature of the bottleneck. Here, we analyze the dynamics of mtDNA heteroplasmy transmission in the Genomes of the Netherlands (GoNL) data, which consists of complete mtDNA genome sequences from 228 trios, eight dizygotic (DZ) twin quartets,...
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