Article
Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer.
PloS one - 1 Jan 2016
Jee Youn Hee, Sadowski Samira M, Celi Francesco S, Xi Liqiang, Raffeld Mark, Sacks David B, Remaley Alan T, Wellstein Anton, Kebebew Electron, Baron Jeffrey
Abstract excerpt
BACKGROUND: Thyroid nodules are common, and approximately 5% of these nodules are malignant. Pleiotrophin (PTN) is a heparin-binding growth factor which is overexpressed in many cancers. The expression of PTN in papillary thyroid cancer (PTC) is unknown. METHOD AND FINDINGS: 74 subjects (age 47 ± 12 y, 15 males) who had thyroidectomy with a histological diagnosis: 79 benign nodules and 23 PTCs (10 classic, 6 tall...
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