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Article

Aging is associated with hypermethylation of autophagy genes in macrophages

25 Feb 2016

Abstract excerpt

Autophagy is a biological process characterized by self-digestion and involves induction of autophagosome formation, leading to degradation of autophagic cargo. Aging is associated with the reduction of autophagy activity leading to neurodegenerative disorders, chronic inflammation, and susceptibility to infection; however, the underlying mechanism is unclear. DNA methylation by DNA methyltransferases reduces the...

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PMID: 26909551
DOI: 10.1080/15592294.2016.1144007

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