Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphatase and Tensin Homolog Is a Potential Target for Ovarian Cancer Sensitization to Cytotoxic Agents.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 May 2016

McCormick Aiste, Earp Eleanor, Leeson Charlotte, Dixon Michelle, O'Donnell Rachel, Kaufmann Angelika, Edmondson Richard J

Abstract excerpt

OBJECTIVES: The phosphatase and tensin homolog (PTEN) tumor suppressor protein has been found to be inactivated or mutated in various human malignancies and to play a role in cisplatin and poly(ADP-ribose) polymerase inhibitor sensitivity. In this study, we assessed the association of PTEN loss with homologous recombination (HR) deficiency and increased chemosensitivity. MATERIALS AND METHODS: The PTEN knockdown...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma, Clear Cell
Share to Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endometrial Neoplasms

Share to Fluorescent Antibody Technique

Share to Prostatic Neoplasms

Share to PTEN Phosphohydrolase

Share to Real-Time Polymerase Chain Reaction

Share to RNA, Small Interfering

Source

Identifiers

PMID: 26905328
DOI: 10.1097/IGC.0000000000000657

Genes

PTEN
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphatase and Tensin Homolog Is a Potential Target for Ovarian Cancer Sensitization to Cytotoxic Agents.PMID 26905328Read ↗

PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapySemantic proximity Read ↗

Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors.Semantic proximity Read ↗

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.Semantic proximity Read ↗

Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell DeathSemantic proximity Read ↗

Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell deathSemantic proximity Read ↗

Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer.Semantic proximity Read ↗

PTEN loss confers sensitivity to rapalogs in clear cell renal cell carcinoma.Semantic proximity Read ↗

Role of PARylation and PTEN Mutation on PARP and PARG Inhibitor Efficacy on GlioblastomaSemantic proximity Read ↗

Deletion of PTEN Promotes Tumorigenic Signaling, Resistance to Anoikis, and Altered Response to Chemotherapeutic Agents in Human Mammary Epithelial CellsSemantic proximity Read ↗

PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous RecombinationSemantic proximity Read ↗

PTEN-negative endometrial cancer cells protect their genome through enhanced DDB2 expression associated with augmented nucleotide excision repairSemantic proximity Read ↗

RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational StatusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.