Article
Increasing Clinical Severity during a Dengue Virus Type 3 Cuban Epidemic: Deep Sequencing of Evolving Viral Populations.
Journal of virology - 1 May 2016
Rodriguez-Roche Rosmari, Blanc Hervé, Bordería Antonio V, Díaz Gisell, Henningsson Rasmus, Gonzalez Daniel, Santana Emidalys, Alvarez Mayling, Castro Osvaldo, Fontes Magnus, Vignuzzi Marco, Guzman Maria G
Abstract excerpt
UNLABELLED: During the dengue virus type 3 (DENV-3) epidemic that occurred in Havana in 2001 to 2002, severe disease was associated with the infection sequence DENV-1 followed by DENV-3 (DENV-1/DENV-3), while the sequence DENV-2/DENV-3 was associated with mild/asymptomatic infections. To determine the role of the virus in the increasing severity demonstrated during the epidemic, serum samples collected at...
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