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RAB18, a protein associated with Warburg Micro syndrome, controls neuronal migration in the developing cerebral cortex

15 Feb 2016

Abstract excerpt

BACKGROUND: Loss of function mutations in RAB18, has been identified in patients with the human neurological and developmental disorder Warburg Micro syndrome. However, the function of RAB18 in brain remains unknown. RESULTS: In this study, we report that RAB18 is a critical regulator of neuronal migration and morphogenesis. Using in utero electroporation suppression of RAB18 in the mouse brain impairs radial...

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PMID: 26879639
DOI: 10.1186/s13041-016-0198-2

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