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Diet-induced changes in maternal gut microbiota and metabolomic profiles influence programming of offspring obesity risk in rats

12 Feb 2016

Abstract excerpt

Maternal obesity and overnutrition during pregnancy and lactation can program an increased risk of obesity in offspring. In this context, improving maternal metabolism may help reduce the intergenerational transmission of obesity. Here we show that, in Sprague-Dawley rats, selectively altering obese maternal gut microbial composition with prebiotic treatment reduces maternal energy intake, decreases gestational...

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PMID: 26868870
DOI: 10.1038/srep20683

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