Article
Analysis of mitochondrial DNA alteration in new phenotype ACOS.
BMC pulmonary medicine - 12 Feb 2016
Carpagnano G E, Lacedonia D, Malerba M, Palmiotti G A, Cotugno G, Carone M, Foschino-Barbaro M P
Abstract excerpt
BACKGROUND: Mitochondria contain their own DNA (MtDNA) that is very sensitive to oxidative stress and as a consequence could be damaged in quantity. Oxidative stress is largely recognized to play a key role in the pathogenesis of asthma and COPD and might have a role in the new intermediate phenotype ACOS (asthma-COPD overlap syndrome). The aim of this study was to investigate MtDNA alterations, as an expression...
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