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What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast

1 Feb 2016

Abstract excerpt

Controversy surrounds reports describing the derivation of human trophoblast cells from placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers that define cells as belonging to the trophoblast lineage. We have selected criteria that are characteristic of primary first-trimester trophoblast: a set of protein markers, HLA class I profile, methylation of ELF5, and expression of...

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PMID: 26862703
DOI: 10.1016/j.stemcr.2016.01.006

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