Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment

6 Feb 2016

Abstract excerpt

Calcification of soft tissues, such as heart valves and tendons, is a common clinical problem with limited therapeutics. Tissue specific stem/progenitor cells proliferate to repopulate injured tissues. But some of them become divergent to the direction of ossification in the local pathological microenvironment, thereby representing a cellular target for pharmacological approach. We observed that HIF-2alpha...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Shoulder Injury and Treatment
Share to Sports injuries and prevention
Share to Tendon Structure and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26851078
DOI: 10.1002/stem.2306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification TreatmentPMID 26851078Read ↗

Overexpression of mechanical sensitive miR-337-3p alleviates ectopic ossification in rat tendinopathy model via targeting IRS1 and Nox4 of tendon-derived stem cellsSemantic proximity Read ↗

Molecular dissection of tendon development and healing: Insights into tenogenic phenotypes and functions.Semantic proximity Read ↗

The role of the blood on the heterotopic ossification of the injured tendon through PI3K/AKT signaling pathwaySemantic proximity Read ↗

Role of endothelial cells in vascular calcificationSemantic proximity Read ↗

Insights into bone morphogenetic proteins in cardiovascular diseasesSemantic proximity Read ↗

Knockdown of SERPINB2 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signalling pathwaySemantic proximity Read ↗

Arterial calcification: Finger-pointing at resident and circulating stem cellsSemantic proximity Read ↗

Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine ExosomesSemantic proximity Read ↗

A genome-wide analysis of the gene expression profiles and alternative splicing events during the hypoxia-regulated osteogenic differentiation of human cartilage endplate-derived stem cellsSemantic proximity Read ↗

A novel role of cellular interactions in vascular calcificationSemantic proximity Read ↗

Molecular and biophysical mechanisms regulating hypertrophic differentiation in chondrocytes and mesenchymal stem cellsSemantic proximity Read ↗

MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under HypoxiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.