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Article

Targeted Next-Generation Sequencing of a Deafness Gene Panel (MiamiOtoGenes) Analysis in Families Unsuitable for Linkage Analysis.

BioMed research international - 1 Jan 2018

Shang Haiqiong, Yan Denise, Tayebi Naeimeh, Saeidi Kolsoum, Sahebalzamani Afsaneh, Feng Yong, Blanton Susan, Liu Xuezhong

Abstract excerpt

Hearing loss (HL) is a common sensory disorder in humans with high genetic heterogeneity. To date, over 145 loci have been identified to cause nonsyndromic deafness. Furthermore, there are countless families unsuitable for the conventional linkage analysis. In the present study, we used a custom capture panel (MiamiOtoGenes) to target sequence 180 deafness-associated genes in 5 GJB2 negative deaf probands with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29568747
DOI: 10.1155/2018/3103986
PMCID: PMC5820677

Genes

CDH23
GJB2
LHFPL5
PCDH15
TRIOBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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