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Article

Association of CYP2C19*2 and associated haplotypes with lower norendoxifen concentrations in tamoxifen-treated Asian breast cancer patients.

British journal of clinical pharmacology - 1 Jun 2016

Lim Joanne Siok Liu, Sutiman Natalia, Muerdter Thomas E, Singh Onkar, Cheung Yin Bun, Ng Raymond Chee Hui, Yap Yoon Sim, Wong Nan Soon, Ang Peter Cher Siang, Dent Rebecca, Schroth Werner, Schwab Matthias, Chowbay Balram

Abstract excerpt

AIM: The aim was to examine the influence of CYP2C19 variants and associated haplotypes on the disposition of tamoxifen and its metabolites, particularly norendoxifen (NorEND), in Asian patients with breast cancer. METHODS: Sixty-six CYP2C19 polymorphisms were identified in healthy Asians (n = 240), of which 14 were found to be tightly linked with CYP2C19*2, CYP2C19*3 and CYP2C19*17. These 17 SNPs were further...

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Identifiers

PMID: 26799162
DOI: 10.1111/bcp.12886
PMCID: PMC4876188

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