Article
Metabolomics profiling reveals novel markers for leukocyte telomere length.
Aging - 1 Jan 2016
Zierer Jonas, Kastenmüller Gabi, Suhre Karsten, Gieger Christian, Codd Veryan, Tsai Pei-Chien, Bell Jordana, Peters Annette, Strauch Konstantin, Schulz Holger, Weidinger Stephan, Mohney Robert P, Samani Nilesh J, Spector Tim, Mangino Massimo, Menni Cristina
Abstract excerpt
Leukocyte telomere length (LTL) is considered one of the most predictive markers of biological aging. The aim of this study was to identify novel pathways regulating LTL using a metabolomics approach. To this end, we tested associations between 280 blood metabolites and LTL in 3511 females from TwinsUK and replicated our results in the KORA cohort. We furthermore tested significant metabolites for associations...
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