Article
Germline SFTPA1 mutation in familial idiopathic interstitial pneumonia and lung cancer.
Human molecular genetics - 15 Apr 2016
Nathan Nadia, Giraud Violaine, Picard Clément, Nunes Hilario, Dastot-Le Moal Florence, Copin Bruno, Galeron Laurie, De Ligniville Alice, Kuziner Nathalie, Reynaud-Gaubert Martine, Valeyre Dominique, Couderc Louis-Jean, Chinet Thierry, Borie Raphaël, Crestani Bruno, Simansour Maud, Nau Valérie, Tissier Sylvie, Duquesnoy Philippe, Mansour-Hendili Lamisse, Legendre Marie, Kannengiesser Caroline, Coulomb-L'Hermine Aurore, Gouya Laurent, Amselem Serge, Clement Annick
Abstract excerpt
Idiopathic interstitial pneumonias (IIPs) comprise a heterogeneous group of rare lung parenchyma disorders with high morbidity and mortality, which can occur at all ages. In adults, the most common form of IIPs, idiopathic pulmonary fibrosis (IPF), has been associated with an increased frequency of lung cancer. The molecular basis of IIPs remains unknown in most cases. This study investigates IIP pathophysiology...
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