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Genotyping Yersinia pestis in Historical Plague: Evidence for Long-Term Persistence of Y. pestis in Europe from the 14th to the 17th Century.

PloS one - 1 Jan 2016

Seifert Lisa, Wiechmann Ingrid, Harbeck Michaela, Thomas Astrid, Grupe Gisela, Projahn Michaela, Scholz Holger C, Riehm Julia M

Abstract excerpt

Ancient DNA (aDNA) recovered from plague victims of the second plague pandemic (14th to 17th century), excavated from two different burial sites in Germany, and spanning a time period of more than 300 years, was characterized using single nucleotide polymorphism (SNP) analysis. Of 30 tested skeletons 8 were positive for Yersinia pestis-specific nucleic acid, as determined by qPCR targeting the pla gene. In one...

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PMID: 26760973
DOI: 10.1371/journal.pone.0145194
PMCID: PMC4712009

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