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Article

MicroRNA-124 Controls Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in the Retinal Pigment Epithelium by Targeting RHOG.

1 Jan 2016

Abstract excerpt

PURPOSE: MicroRNA-124 (miR-124) is thought to be involved in the epithelial-mesenchymal transition (EMT) of RPE. We investigated the regulation of TGF-β1-induced EMT by miR-124 in human RPE cells (ARPE-19). METHODS: Expression of miR-124 was evaluated after TGF-β1 treatment by quantitative RT-PCR. Phenotypic alterations were analyzed by Western blot analysis and immunocytochemical staining. Target validation was...

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PMID: 26746014
DOI: 10.1167/iovs.15-17111

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