Article
Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies.
American journal of respiratory and critical care medicine - 15 Jun 2016
Belvisi Maria G, Birrell Mark A, Khalid Saifudin, Wortley Michael A, Dockry Rachel, Coote Julie, Holt Kimberley, Dubuis Eric, Kelsall Angela, Maher Sarah A, Bonvini Sara, Woodcock Ashley, Smith Jaclyn A
Abstract excerpt
RATIONALE: Most airway diseases, including chronic obstructive pulmonary disease (COPD), are associated with excessive coughing. The extent to which this may be a consequence of increased activation of vagal afferents by pathology in the airways (e.g., inflammatory mediators, excessive mucus) or an altered neuronal phenotype is unknown. Understanding whether respiratory diseases are associated with dysfunction of...
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