Article
Selection and mutation in X-linked recessive diseases epidemiological model.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference - 1 Jan 2015
Verrilli Francesca, Kebriaei Hamed, Glielmo Luigi, Corless Martin, Del Vecchio Carmen
Abstract excerpt
To describe the epidemiology of X-linked recessive diseases we developed a discrete time, structured, non linear mathematical model. The model allows for de novo mutations (i.e. affected sibling born to unaffected parents) and selection (i.e., distinct fitness rates depending on individual's health conditions). Applying Lyapunov direct method we found the domain of attraction of model's equilibrium point and...
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